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Acute exercise effect on postabsorptive serum leptin.

J S Fisher1, R E Van Pelt, O Zinder

  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. jfisher@im.wustl.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 18, 2001
PubMed
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Intense exercise transiently alters serum leptin levels, with rapid changes linked to hemoconcentration. Leptin mass ultimately increases post-exercise, potentially due to elevated plasma glucose.

Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Metabolic Research

Background:

  • Leptin, a key regulator of energy balance, is influenced by various physiological states.
  • The relationship between acute exercise, cortisol, and leptin dynamics requires further elucidation.

Purpose of the Study:

  • To investigate the impact of intense exercise on serum leptin concentrations in young, lean men.
  • To determine if elevated cortisol levels during exercise correlate with changes in serum leptin.

Main Methods:

  • Participants underwent a 41-minute cycle ergometer exercise session or a rest control condition after a small meal.
  • Serum leptin, cortisol, protein, and glucose concentrations were measured at baseline, during exercise, and during recovery.

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Main Results:

  • Serum leptin was 10% higher during exercise and 10% lower immediately post-exercise compared to control.
  • Rapid leptin changes were attributed to hemoconcentration, not leptin mass.
  • Normalized leptin (to serum protein) increased by 10% post-exercise, independent of cortisol levels.
  • Increased leptin mass post-exercise correlated with higher plasma glucose levels.

Conclusions:

  • Acute exercise transiently affects serum leptin concentration, with rapid changes mediated by hemoconcentration.
  • Leptin mass increases after exercise, potentially linked to enhanced glucose availability during recovery.
  • Cortisol response to exercise does not directly explain exercise-induced alterations in leptin.