Risk factors of catheter-related infections in total parenteral nutrition catheterization

The use of central venous catheter for administration of total parenteral nutrition (TPN) is a risk factor of catheter-related infections (CRIs) that are associated with increased morbidity and mortality, prolonged hospitalization, and increased medical costs. The purpose of this study is to evaluate the risk factors of CRIs in patients with administration of TPN.

A total of 1134 patients receiving TPN between January, 1996 and December, 1998 were studied. The category of infection included definite catheter-related bloodstream infection (CR-BSI), probable CR-BSI, and insertion site infection. Statistical analysis of risk factors was performed.

A total of 131 episodes of CRI occurred, representing an infection rate of 11.46%. Ninety-three episodes (8.1%) had probable CR-BSI, 13 episodes (1.1%) had definite CR-BSI, and 25 episodes (2.2%) had insertion site infection. Duration of TPN infusion and frequency of catheter insertion showed statistically significant difference by logistic regression multivariate analysis. The isolated organisms were in sequence of coagulase-negative Staphylococci (19.4%), Staphylococcus aureus (17.2%) and Candida albicans (14.4%).

Risk factors influencing the occurrence of CRI in TPN administration were multifactorial; however, duration of TPN infusion and frequency of catheter insertion were the main factors in our study.