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Does the estrogen receptor gene polymorphism relate to undefined menopausal symptoms?
T Ushiroyama1, M Heishi, A Ikeda
1Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Japan. gyn003@poh.osaka-med.ac.jp
Research Communications in Molecular Pathology and Pharmacology
|July 19, 2001
Summary
Estrogen receptor (ER) gene polymorphism influences the aging of the genitospinal center. This genetic variation may contribute to unexplained perimenopausal symptoms in women.
Area of Science:
- Genetics
- Endocrinology
- Women's Health
Background:
- The aging process of the genitospinal center is not fully understood.
- Estrogen receptor (ER) gene polymorphism's role in menopausal symptoms requires further investigation.
Purpose of the Study:
- To examine the relationship between ER gene polymorphism and undefined complaints.
- To clarify the aging process of the genitospinal center in relation to ER gene variants.
Main Methods:
- Analyzed Pvu II and Xba I restriction fragment length polymorphism (RFLP) of the ER gene in 507 Japanese women.
- Classified participants into three groups based on serum estradiol (E2) levels.
- Correlated ER genotypes with menopausal symptoms and hormone levels (FSH, LH, E2).
Main Results:
- Genotype Pp was more frequent in women with higher E2 levels (Group A).
- The Ppxx genotype was more common in Group A compared to Groups B or C.
- The ppxx genotype was less frequent in Group A than in Groups B or C.
- Plasma estradiol levels differed significantly between Ppxx and ppxx genotypes.
- Higher incidence of mental symptoms was observed in Group A.
Conclusions:
- ER gene polymorphism appears to influence the aging of the genitospinal center.
- Genetic variations in the ER gene may partly explain the pathophysiology of undefined perimenopausal complaints.