Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperhomocysteinemia in dementia.

F Leblhuber1, J Walli, E Artner-Dworzak

  • 1Department of Gerontology, Landesnervenklinik Wagner Jauregg, Linz, Austria.

Journal of Neural Transmission (Vienna, Austria : 1996)
|July 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moderate hyperhomocysteinaemia and immune activation in Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2002
Same author

Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.

British journal of cancer·2002
Same author

Increased neopterin production and tryptophan degradation in advanced Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2002
Same author

Neopterin as a marker for immune system activation.

Current drug metabolism·2002
Same author

Hyperhomocysteinemia, pteridines and oxidative stress.

Current drug metabolism·2002
Same author

Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest.

Mediators of inflammation·2002

Elevated homocysteine levels are linked to dementia and vitamin B deficiency. This study found high homocysteine and low folic acid correlate with cognitive decline in dementia patients, suggesting folic acid supplementation may help.

Area of Science:

  • Neurology
  • Biochemistry
  • Nutritional Science

Background:

  • Hyperhomocysteinemia is a known risk factor for atherosclerotic vascular disease.
  • Elevated serum homocysteine levels are often correlated with vitamin B deficiencies.

Purpose of the Study:

  • To investigate the association between homocysteine levels and cognitive decline in patients with dementia.
  • To explore the potential role of folic acid in managing hyperhomocysteinemia in dementia.

Main Methods:

  • Pilot study involving patients diagnosed with Alzheimer's disease and vascular dementia.
  • Measurement of serum homocysteine and folic acid concentrations.
  • Correlation analysis between homocysteine/folic acid levels and cognitive status.

Related Experiment Videos

Main Results:

  • Significantly elevated homocysteine levels were observed in patients with both Alzheimer's disease and vascular dementia.
  • A significant correlation was found between low folic acid concentrations and cognitive decline.
  • High homocysteine concentrations were also significantly correlated with cognitive decline.

Conclusions:

  • Elevated homocysteine and low folic acid are associated with cognitive decline in dementia patients, suggesting shared pathophysiological pathways.
  • Folic acid supplementation presents a potential, cost-effective strategy for reducing homocysteine levels in demented individuals.