Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Neopterin as a marker for immune system activation.

C Murr¹, B Widner, B Wirleitner

¹Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.

Current Drug Metabolism

|May 11, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Andrological findings in infertile men with two (biallelic) CFTR mutations: results of a multicentre study in Germany and Austria comprising 71 patients.

Human reproduction (Oxford, England)·2020

Same author

Relationship between follicular volume and oocyte competence, blastocyst development and live-birth rate: optimal follicle size for oocyte retrieval.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2017

Same author

Pregnancy and birth outcomes following fresh or vitrified embryo transfer according to blastocyst morphology and expansion stage, and culturing strategy for delayed development.

Human reproduction (Oxford, England)·2016

Same author

Implications of Blood Type for Ovarian Reserve and Infertility - Impact on Oocyte Yield in IVF Patients.

Geburtshilfe und Frauenheilkunde·2014

Same author

Adnexal Torsion in Pregnancy after Assisted Reproduction - Case Study and Review of the Literature.

Geburtshilfe und Frauenheilkunde·2014

Same author

The time aspect in storing vitrified blastocysts: its impact on survival rate, implantation potential and babies born.

Human reproduction (Oxford, England)·2013

Neopterin levels indicate cellular immune activation and oxidative stress. Measuring neopterin in body fluids aids in diagnosing infections, autoimmune diseases, and monitoring organ transplant recipients.

Area of Science:

Immunology
Biochemistry
Clinical Diagnostics

Background:

Human monocytes/macrophages increase neopterin production when stimulated by interferon-gamma.
Neopterin concentrations in body fluids reflect T helper cell 1-mediated immune activation.

Purpose of the Study:

To highlight the diagnostic and prognostic applications of neopterin measurements.
To establish neopterin as a marker for both cellular immune activation and oxidative stress.

Main Methods:

Measurement of neopterin concentrations in various body fluids (serum, cerebrospinal fluid, urine).
Correlation of neopterin levels with different disease states and immune responses.

Main Results:

Elevated neopterin is observed in viral infections (including HIV), bacterial/parasitic infections, autoimmune diseases, cancers, and allograft rejection.

Related Experiment Videos

Neopterin levels correlate with disease progression and survival in certain conditions like cancer and HIV.

Neopterin production is linked to increased reactive oxygen species and decreased antioxidant levels.

Conclusions:

Neopterin measurement is a valuable tool for diagnosing and monitoring a wide range of immune-related conditions.
Neopterin serves as a dual marker for cellular immune activation and oxidative stress.
Neopterin screening in blood donations can enhance transfusion safety by detecting acute infections.