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[Acitretine].

P Berbis1

  • 1Service de Dermatologie, Hôpital Nord, Chemin des Bourrellys, 13015 Marseille. pberbis@ap-hm.fr

Annales De Dermatologie Et De Venereologie
|July 19, 2001
PubMed
Summary
This summary is machine-generated.

Acitretin, an aromatic retinoid, treats various skin conditions but is a potent teratogen requiring strict contraception. Alcohol intake can prolong its effects, necessitating caution during and after treatment.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Teratology

Context:

  • Acitretin is an aromatic retinoid used for treating psoriasis and other keratinization disorders.
  • It is a metabolite of etretinate with a moderate elimination half-life, but alcohol can convert it to a longer-acting form.

Purpose:

  • To review the efficacy, indications, and adverse effects of acitretin in dermatological conditions.
  • To highlight the teratogenic potential and drug interactions of acitretin.

Summary:

  • Acitretin is effective for pustular psoriasis, psoriatic palmo-plantar keratoderma, ichthyosis, Darier's disease, and severe lichen planus.
  • It also prevents skin carcinomas in high-risk patients.
  • Common side effects include mucocutaneous issues and elevated liver enzymes or lipids; bone changes and growth issues in children are noted.

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  • Contraindications include concomitant use with hepatotoxic drugs like methotrexate or tetracyclines due to severe risks.

    • Impact:

    • Acitretin provides a valuable therapeutic option for severe dermatological conditions.
    • Understanding its pharmacokinetics, teratogenicity, and interactions is crucial for safe and effective patient management.
    • Physicians must counsel patients on risks, especially teratogenicity and the impact of alcohol consumption.