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Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages
E Aldieri1, D Ghigo, M Tomatis
1Department of Genetics, Biology, and Biochemistry, University of Torino, Via Santena, 5/bis-10126 Torino, Italy. dario.ghigo@unito.it
Free Radical Biology & Medicine
|July 20, 2001
Abstract:
Crocidolite fibers stimulated nitric oxide synthase (NOS) activity and expression in glial and alveolar murine macrophages: this effect was inhibited by iron supplementation and enhanced by iron chelation. We suggest that in these cells crocidolite stimulates NOS expression by decreasing the iron bioavailability and activating an iron-sensitive transcription factor.