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Related Experiment Videos

Does reversal of ischemia on diffusion-weighted imaging reflect higher apparent diffusion coefficient values?

H L Lutsep1, G M Nesbit, R M Berger

  • 1Oregon Stroke Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97201, USA. lutseph@ohsu.edu

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|July 21, 2001
PubMed
Summary

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Reversible ischemic lesions on diffusion-weighted imaging (DWI) show higher apparent diffusion coefficients (ADCs). This suggests that thrombolytic therapy can lead to significant lesion reversal in stroke patients.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Diffusion-weighted imaging (DWI) is crucial for early stroke detection.
  • Apparent diffusion coefficients (ADCs) quantify water diffusion in tissues, aiding in stroke characterization.
  • Understanding lesion reversibility is key for assessing treatment efficacy.

Observation:

  • Serial magnetic resonance imaging (MRI) was performed on a patient treated with thrombolytics.
  • A large left frontoparietal stroke on baseline DWI significantly reduced in size by 4 weeks.
  • Fluid attenuated inversion recovery (FLAIR) imaging showed substantial lesion resolution.

Findings:

  • Regions of ischemia that reversed on DWI exhibited higher mean ADCs compared to persistent regions.
  • The mean ADC in reversed areas was 7.43 x 10(-3) mm2/s versus 7.31 x 10(-3) mm2/s in persistent areas (P < .036).

Related Experiment Videos

  • These findings indicate a correlation between higher ADCs and lesion reversibility post-thrombolysis.

    • Implications:

    • Large ischemic lesions identified on DWI may be amenable to reversal with thrombolytic treatment.
    • Higher ADCs in specific regions could predict lesion resolution.
    • This research contributes to optimizing stroke treatment strategies and prognostic assessments.