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Published on: June 9, 2015
Protective effect of docosahexaenoic acid against retinal ischemic injury: an electroretinographic study
O Miyauchi1, A Mizota, E Adachi-Usami
1Department of Ophthalmology, Chiba University School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba City, Chiba 260-8670, Japan. miyaucho@ho.chiba-u.ac.jp
Purpose:
To determine whether docosahexaenoic acid (DHA) can reduce the retinal damage induced by transient retinal ischemia.
Methods:
Retinal ischemia was induced by increasing intraocular pressure (IOP). Retinal circulation was restored by lowering IOP. An intraperitoneal injection of 1,000 mg/kg of DHA-ester (DHA-E) was given 5 h before the ischemia. Electroretinograms were recorded just before the ischemia and at 60-min intervals up to 4 h after circulation was restored.
Results:
The ratio of the amplitudes after the ischemia to that just before ischemia was significantly higher in eyes administered DHA-E than in controls at each time point (p < 0.01).
Conclusion:
DHA-E is effective in protecting the retina against transient retinal ischemia.
