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Related Concept Videos

Phylogenetic Trees03:21

Phylogenetic Trees

Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.The length of the branches can depict time or the relative amount of change among organisms. For instance, the branch length might indicate the number of amino acid changes in the sequence that underlies the...
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 6, 2014

Phylogenetic--evolutionary approaches to bioinformatics.

M Pagel1

  • 1School of Animal and Microbial Sciences, University of Reading, UK. m.pagel@reading.ac.uk

Briefings in Bioinformatics
|July 24, 2001
PubMed
Summary
This summary is machine-generated.

Phylogenetic analysis is crucial for understanding evolution. This study details how phylogenies aid in gene evolution research, from site variability to gene duplication events.

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Last Updated: Jun 29, 2026

A Practical Guide to Phylogenetics for Nonexperts
12:00

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Published on: February 6, 2014

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

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Published on: August 14, 2018

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

Area of Science:

  • Bioinformatics and Evolutionary Biology.

Background:

  • Phylogenies are fundamental to evolutionary biology research.
  • Statistical analyses in bioinformatics often require phylogenetic considerations.

Purpose of the Study:

  • To demonstrate the diverse applications of phylogenies in evolutionary research.
  • To provide a comprehensive overview of how phylogenetic methods can address key questions in molecular evolution.

Main Methods:

  • Utilizing phylogenetic principles to analyze gene sequence data.
  • Applying statistical and phylogenetic methods for evolutionary inference.

Main Results:

  • Phylogenies enable investigation of gene site variability.
  • Reconstruction of ancestral gene and protein states is facilitated by phylogenies.
  • Phylogenies help identify gene duplication and parallel/convergent evolution.
  • Analysis of molecular clock predictions and correlated evolutionary changes.

Conclusions:

  • Phylogenetic analysis offers a powerful framework for studying molecular evolution.
  • A presented table outlines relevant statistical and phylogenetic methods for researchers.