The first year of the toxicology program.

Area of Science:

• Toxicology
• Clinical Chemistry
• Forensic Science

Background:

• The College of American Pathologists (CAP) Toxicology Survey Program was established to improve laboratory testing accuracy.
• Accurate drug testing is crucial for clinical diagnostics and forensic investigations.

Purpose of the Study:

• To review the initial year of the CAP Toxicology Survey Program.
• To assess the performance of laboratories in drug identification and quantification.
• To enhance the "current state of the art" in clinical and forensic toxicology.

Main Methods:

• Distributed four series of specimens (serum and urine) containing approximately 12 drugs each to nearly 200 participants.
• Participants performed qualitative and quantitative analyses for over 16 compounds, including specific barbiturate identification.
• Utilized clinically relevant samples reflecting current drug abuse patterns, including mixed-drug abuse scenarios.

Main Results:

• Participants reported on the presence or absence of over 16 compounds.
• Specific barbiturates were identified accurately when present.
• Both qualitative and quantitative analyses were performed on serum and urine samples.

Conclusions:

• The initial year of the CAP Toxicology Survey Program successfully engaged participants in improving drug testing capabilities.
• The program prioritized drug-abuse toxicology and therapeutic drug monitoring, providing relevant clinical scenarios.
• Ongoing interaction through critiques and questionnaires facilitates continuous improvement among participants.