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Growth hormone binding protein in normal and aneuploid pregnancy: a paradoxical decrease in trisomy 18.

E M Wallace1, D D'Antona, T Veveris-Lowe

  • 1Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.

BJOG : an International Journal of Obstetrics and Gynaecology
|July 27, 2001
PubMed
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Growth hormone binding protein (GHBP) levels were lower in pregnancies with trisomy 18, suggesting a link to fetal growth restriction. Trisomy 21 pregnancies showed normal GHBP levels.

Area of Science:

  • Endocrinology
  • Genetics
  • Maternal-Fetal Medicine

Background:

  • Fetal aneuploidies, such as trisomy 18 and trisomy 21, are associated with significant growth restriction.
  • The role of growth hormone binding protein (GHBP) in fetal growth is not fully understood.
  • Investigating GHBP may reveal mechanisms underlying growth abnormalities in aneuploidies.

Purpose of the Study:

  • To investigate potential abnormalities in maternal growth hormone binding protein (GHBP) levels in pregnancies affected by fetal aneuploidy.
  • To determine if altered GHBP levels correlate with the growth restriction observed in trisomy 18 and trisomy 21.

Main Methods:

  • A retrospective case-control study was conducted.
  • GHBP levels were measured in maternal serum from 15-18 weeks gestation.

Related Experiment Videos

  • Cases included pregnancies with trisomy 18 (n=21) and trisomy 21 (n=30), compared to 170 chromosomally normal controls.

    • Main Results:

    • Maternal GHBP levels showed a slight, significant decrease across gestation in normal pregnancies.
    • GHBP levels were similar to controls in trisomy 21 pregnancies (1.0 MoM).
    • Significantly reduced GHBP levels were observed in trisomy 18 pregnancies (0.68 MoM).

    Conclusions:

    • Decreased maternal GHBP levels are associated with trisomy 18.
    • This reduction in GHBP may contribute to the severe early growth restriction characteristic of trisomy 18.
    • GHBP may play a role in mediating growth in aneuploid pregnancies.