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Defining Substrate Specificities for Lipase and Phospholipase Candidates
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A structural account of substrate and inhibitor specificity differences between two naphthol reductases

D I Liao1, J E Thompson, S Fahnestock

  • 1Experimental Station, DuPont Central Research and Development, Wilmington, Delaware 19880, USA. der-ing.liao@usa.dupont.com

Biochemistry
|July 27, 2001
PubMed
Summary

Two fungal reductases, 4HNR and 3HNR, show distinct specificities for naphthol substrates and pyroquilon inhibitors. C-terminal residues in these enzymes determine these differences in fungal melanin biosynthesis.

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