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Related Experiment Videos

Enalapril-induced eosinophilic gastroenteritis.

N Barak1, J Hart, M D Sitrin

  • 1University of Chicago, Chicago, Illinois, USA.

Journal of Clinical Gastroenterology
|July 27, 2001
PubMed
Summary
This summary is machine-generated.

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A rare case of eosinophilic gastroenteritis was linked to enalapril, an ACE inhibitor. Discontinuing the medication resolved the patient's chronic diarrhea and eosinophilia.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Eosinophilic gastroenteritis (EG) is a rare gastrointestinal disorder with unknown causes.
  • Angiotensin-converting enzyme (ACE) inhibitors are commonly prescribed for hypertension and heart failure.

Observation:

  • A 63-year-old woman presented with chronic diarrhea and elevated blood eosinophil counts.
  • Her symptoms began after starting enalapril, an ACE inhibitor.

Findings:

  • Small bowel biopsy confirmed eosinophilic infiltration of the lamina propria and epithelium.
  • Discontinuation of enalapril led to rapid resolution of diarrhea and normalization of eosinophil levels.

Implications:

  • This case suggests a potential link between ACE inhibitors, specifically enalapril, and eosinophilic gastroenteritis.

Related Experiment Videos

  • Clinicians should consider ACE inhibitors in the differential diagnosis for patients with unexplained gastrointestinal symptoms and eosinophilia.