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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
[Physiopathology of chronic respiratory insufficiency]
1Service de pneumologie et réanimation Groupe hospitalier La Pitié-La Salpêtrière 75651 Paris. thomas.similowski@psl.ap-hop-paris.fr
Abstract:
The host of chronic respiratory abnormalities responsible for an abnormal hematosis or for a handicap can be termed generically as chronic respiratory insufficiency. Hypoxemia can be the consequence of perturbations of oxygen transfer (fibrosis), of abnormal ventilation-perfusion ratios (venous admixture, chronic obstructive pulmonary disease [COPD]), or of hypoventilation (neuromuscular diseases). Hypercapnia can stem from hypoventilation (neuromuscular diseases), or from abnormal ventilation-perfusion ratios (dead space effect) (COPD). An imbalance between the capacity of the respiratory muscle to produce negative inspiratory pressures and the load they are faced with is a source of hypercapnia, and of dyspnoea and handicap independently of hematosis (COPD, neuromuscular diseases). The effects of hypoxemia on cellular functions make chronic respiratory insufficiency a systemic disease.
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