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Related Experiment Video

Updated: Jul 14, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Published on: January 24, 2025

[Syphilis and pregnancy].

Najeh Hcini^1,2, Asmaa Tazi³, Romane Cousin¹

¹Service de gynécologie-obstétrique, CHU de Guyane site de Saint-Laurent-du-Maroni, Guyane française.

La Revue Du Praticien

|July 13, 2026

Summary

Syphilis infection during pregnancy poses risks to the fetus, potentially causing severe complications. Early screening and treatment are crucial for reducing congenital syphilis impact worldwide.

Keywords:

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Last Updated: Jul 14, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Published on: January 24, 2025

Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Maternal-Fetal Medicine

Background:

Syphilis, caused by *Treponema pallidum*, is a sexually and vertically transmitted bacterial infection with a resurgence globally.
Congenital syphilis is a significant concern during pregnancy, with transmission possible from the 16th week of gestation.
Maternal-fetal transmission is more frequent in early syphilis stages, leading to potential placental and fetal lesions.

Purpose of the Study:

To highlight the risks and consequences of syphilis during pregnancy.
To emphasize the importance of antenatal screening and management of syphilis.
To underscore the need for a global strategy to reduce congenital syphilis.

Main Methods:

Review of existing literature on syphilis in pregnancy.
Analysis of transmission dynamics and pathological consequences.
Evaluation of diagnostic and monitoring strategies.

Main Results:

Syphilis can cause placental/fetal lesions, polyvisceral involvement, fetal hydrops, premature birth, and fetal death.
Antenatal ultrasound can suggest fetal involvement but cannot exclude it; severity is not term-dependent.
Congenital syphilis in live births is often complicated by prematurity and hypotrophy, leading to sequelae.

Conclusions:

Early screening and treatment during pregnancy are vital for mitigating the impact of syphilis.
Clinical, biological, and ultrasound monitoring during pregnancy and the neonatal period is essential.
A proactive strategy is necessary to reduce the global burden of congenital syphilis.