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Updated: Jul 14, 2026

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
[Emerging infectious diseases in France: what are the risks for pregnancy?]
Najeh Hcini1,2, Charles Egloff3,4,5
1Service de gynécologie-obstétrique, CHU de Guyane, site de Saint-Laurent-du-Maroni, Guyane française.
None:
Emerging arboviral infections, a heterogeneous group with varied mechanisms of action and effects, pose a constant challenge in obstetric practice in overseas departments, with a potential risk of extension to mainland France. Teratogenic emerging arboviral infections such as Zika virus (ZIKV), Venezuelan equine encephalitis virus (VEEV), and more recently Oropouche virus are particularly alarming. Given climate change and globalization, these infections have the potential to spread geographically. Beyond their impact on maternal health, some infections can lead to obstetric complications, fetal and/or neonatal infections, and malformations that may result in long-term neurological and neurosensory sequelae. Their real impact seems to be underestimated. It is crucial to develop a coordinated international response within a global approach that includes human, animal, and environmental health to address the challenges posed by emerging and re-emerging infectious diseases. This may involve vaccine research, improved surveillance methods, and the development of rapid diagnostic tools.
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