Related Experiment Videos
Localized amyloid deposition in trigger finger.
S Cordiner-Lawrie1, J Diaz, P Burge
1Nuffield Orthopaedic Centre, Oxford, UK.
Journal of Hand Surgery (Edinburgh, Scotland)
|July 27, 2001
Summary
Localized amyloid deposition was found in the tendon sheath of over 20% of trigger finger patients over 46. These age-associated deposits may contribute to trigger finger development.
Area of Science:
- Orthopedics
- Pathology
- Rheumatology
Background:
- Trigger finger involves flexor tendon sheath (A1 pulley) degeneration and thickening, causing tendon constriction.
- Idiopathic primary trigger finger is a common condition affecting hand function.
Purpose of the Study:
- To investigate the presence and characteristics of amyloid deposition in idiopathic primary trigger finger.
- To explore the potential link between amyloid and age-related changes in trigger finger.
Main Methods:
- Histopathological examination of tendon sheath tissue from 47 idiopathic primary trigger finger cases.
- Analysis of amyloid presence, location, and association with cellular and degenerative changes.
Main Results:
- Amyloid deposition was identified in 11 cases (23%) of trigger finger.
- Amyloid was exclusively found in patients over 46 years old.
- Deposits were observed around cells and in areas of mucinous/fibrinoid degeneration containing glycosaminoglycans.
Conclusions:
- Localized amyloid deposition occurs in a subset of middle-aged and elderly trigger finger patients.
- The findings suggest amyloid deposition may be an age-associated phenomenon contributing to trigger finger pathology.
- Further research is needed to clarify the pathogenic role of these amyloid deposits.