Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging impairs intestinal immunity.

D L Schmucker1, K Thoreux, R L Owen

  • 1Cell Biology and Aging Section, 151E, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA. coach@itsa.ucsf.edu

Mechanisms of Ageing and Development
|July 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher's Note: "Hemoglycin visible fluorescence induced by x rays" [J. Chem. Phys. 158, 114901 (2023)].

The Journal of chemical physics·2023
Same author

Hemoglycin visible fluorescence induced by x rays.

The Journal of chemical physics·2023
Same author

A Department of Public Health.

Buffalo medical journal·2023
Same author

Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.

Science advances·2021
Same author

Effect of clinical signs, endocrinopathies, timing of surgery, hyperlipidemia, and hyperbilirubinemia on outcome in dogs with gallbladder mucocele.

Veterinary journal (London, England : 1997)·2019
Same author

Time zero determination for FEL pump-probe studies based on ultrafast melting of bismuth.

Structural dynamics (Melville, N.Y.)·2017
Same journal

Human sex-specific hormone effects on cerebrovascular health in males and females.

Mechanisms of ageing and development·2026
Same journal

HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan.

Mechanisms of ageing and development·2026
Same journal

PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts.

Mechanisms of ageing and development·2026
Same journal

Distinct post-infectious TLR2 immune remodeling in COVID-19-recovered centenarians.

Mechanisms of ageing and development·2026
Same journal

Senescence-associated tertiary lymphoid structures in Sjögren's disease model nishiura mice.

Mechanisms of ageing and development·2026
Same journal

Aging-driven reprogramming of CD34⁺ hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications.

Mechanisms of ageing and development·2026
See all related articles

Aging significantly impairs intestinal immunity in older adults, increasing susceptibility to infections. Research indicates a key issue is the reduced migration of immunoglobulin A (IgA) producing cells to the gut lining, compromising mucosal defense.

Area of Science:

  • Immunology
  • Gerontology
  • Gastroenterology

Background:

  • The elderly experience immunosenescence, leading to increased infectious disease risks.
  • Intestinal mucosal immunity shows deficits in aging despite claims of relative preservation.
  • Mechanisms disrupting age-related intestinal immunity are poorly understood.

Purpose of the Study:

  • To investigate age-related changes in intestinal mucosal immune responses.
  • To identify specific mechanisms responsible for diminished gut immunity in the elderly.

Main Methods:

  • Quantitative immunohistochemical analysis of IgA immunoblast migration.
  • In vitro IgA antibody secretion assays.
  • Receptor-binding assays for IgA transport.

Related Experiment Videos

Main Results:

  • Migration of IgA immunoblasts to the intestinal effector site is compromised in aged animals.
  • IgA antibody secretion by intestinal lymphocytes is equivalent in young and old rats.
  • IgA receptor number and binding affinity in enterocytes do not decline with age.

Conclusions:

  • Age-related decline in intestinal mucosal immune responsiveness may stem from impaired homing of IgA immunoblasts.
  • Focusing on immunoblast migration is crucial for understanding and potentially improving gut immunity in the elderly.