Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p73.

P K Davis1, S F Dowdy

  • 1Howard Hughes Medical Institute, Washington University School of Medicine, 4940 Parkview, Campus Box 8022, St. Louis, MO 63110, USA.

The International Journal of Biochemistry & Cell Biology
|July 27, 2001
PubMed
Summary
This summary is machine-generated.

The tumor suppressor p73, a p53 family member, can induce apoptosis and regulate p53 targets. Introducing p73 into cancer cells with inactive p53 offers a potential therapeutic strategy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparison of skin grafting and healing by granulation, following axillary excision for hidradenitis suppurativa.

Annals of the Royal College of Surgeons of England·2009
Same author

Breast reconstruction after failed conservation.

Annals of the Royal College of Surgeons of England·2009
Same author

The use of video self-modelling and feedback to teach cooking skills to individuals with traumatic brain injury: a pilot study.

Brain injury·2006
Same author

Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS.

Journal of virology·2004
Same author

Antitumour effects of PLC-gamma1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells.

British journal of cancer·2004
Same author

Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain.

The American journal of pathology·2001
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • p73, a p53 family member, is being studied for its role in cancer.
  • p73 functions as a transcription factor, regulating p53 targets.
  • p73 can induce apoptosis, similar to p53, in response to DNA damage.

Purpose of the Study:

  • To investigate the function and regulation of p73.
  • To explore the involvement of p73 in tumorigenesis.
  • To evaluate p73 as a potential therapeutic agent.

Main Methods:

  • Literature review on p73 function and regulation.
  • Analysis of p73's role in apoptosis induction.
  • Examination of p73's involvement in tumor suppressor activity.

Related Experiment Videos

Main Results:

  • p73 acts as a transcription factor regulating p53-dependent genes.
  • p73 induces apoptosis, suggesting tumor suppressor functions.
  • p73 gene silencing via hypermethylation observed in some leukemias.

Conclusions:

  • p73 exhibits tumor suppressor activity overlapping with p53.
  • Therapeutic introduction of p73 may benefit tumors with inactive p53.