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p73

P K Davis1, S F Dowdy

  • 1Howard Hughes Medical Institute, Washington University School of Medicine, 4940 Parkview, Campus Box 8022, St. Louis, MO 63110, USA.

The International Journal of Biochemistry & Cell Biology
|July 27, 2001
PubMed

Insights

The tumor suppressor p73, a p53 family member, can induce apoptosis and regulate p53 targets. Introducing p73 into cancer cells with inactive p53 offers a potential therapeutic strategy.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • p73, a p53 family member, is being studied for its role in cancer.
  • p73 functions as a transcription factor, regulating p53 targets.
  • p73 can induce apoptosis, similar to p53, in response to DNA damage.

Purpose of the Study:

  • To investigate the function and regulation of p73.
  • To explore the involvement of p73 in tumorigenesis.
  • To evaluate p73 as a potential therapeutic agent.

Main Methods:

  • Literature review on p73 function and regulation.
  • Analysis of p73's role in apoptosis induction.
  • Examination of p73's involvement in tumor suppressor activity.

Main Results:

  • p73 acts as a transcription factor regulating p53-dependent genes.
  • p73 induces apoptosis, suggesting tumor suppressor functions.
  • p73 gene silencing via hypermethylation observed in some leukemias.

Conclusions:

  • p73 exhibits tumor suppressor activity overlapping with p53.
  • Therapeutic introduction of p73 may benefit tumors with inactive p53.

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