Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural genomics: opportunities and challenges.

P R Mittl1, M G Grütter

  • 1Institute of Biochemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

Current Opinion in Chemical Biology
|July 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency.

Cell death and differentiation·2012
Same author

Generation of human TRIM5alpha mutants with high HIV-1 restriction activity.

Gene therapy·2010
Same author

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

Cell death and differentiation·2009
Same author

nDsbD: a redox interaction hub in the Escherichia coli periplasm.

Cellular and molecular life sciences : CMLS·2006
Same author

Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.

Journal of molecular biology·2001
Same author

Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease.

FEBS letters·2001

Structural genomics uses high-throughput methods to map all protein structures, aiding function prediction. This approach effectively identifies functions for proteins with unknown roles.

Area of Science:

  • Structural biology
  • Genomics
  • Proteomics

Background:

  • Advancements in whole-genome sequencing necessitate new strategies for protein function elucidation.
  • Understanding protein structure is crucial for predicting biological function.

Purpose of the Study:

  • To systematically determine protein structures using high-throughput methods.
  • To create a comprehensive catalog of protein folds and structures.
  • To enhance functional annotation of proteins with unknown roles.

Main Methods:

  • High-throughput structure determination techniques.
  • Systematic structural genomics approaches.
  • Genome sequencing data integration.

Main Results:

Related Experiment Videos

  • Structural genomics is proving effective in identifying protein functions.
  • Initial findings support the utility of structural genomics for functional annotation.
  • A growing inventory of protein structures is being generated.

Conclusions:

  • Structural genomics is a powerful strategy for understanding the proteome.
  • This approach significantly aids in assigning functions to uncharacterized proteins.
  • The systematic determination of protein structures is key to advancing biological knowledge.