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Polymers in drug delivery.

O Pillai1, R Panchagnula

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research, Sector-67, Ph X, SAS Nagar -- 160 062 (Punjab), India.

Current Opinion in Chemical Biology
|July 27, 2001
PubMed
Summary

Novel polymers and advanced drug-delivery systems are emerging, utilizing biodegradable materials and smart hydrogels for targeted therapeutic applications. Future research focuses on polymer combinations for enhanced drug delivery.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Polymer science advancements have enabled novel drug-delivery systems.
  • Surface and bulk properties are crucial for designing effective polymer-based drug delivery.

Purpose of the Study:

  • To review the current landscape and future directions of polymer-based drug delivery systems.
  • To highlight the potential of novel materials and stimuli-responsive systems.

Main Methods:

  • Review of recent literature on polymer science in drug delivery.
  • Analysis of biodegradable polymers, supramolecular structures (copolymers, dendrimers), and hydrogels.
  • Discussion of design principles for advanced drug delivery.

Main Results:

  • Biodegradable polymers offer safe in-vivo degradation into non-toxic monomers.
  • Supramolecular structures like polyethylene oxide copolymers and dendrimers are key for gene and macromolecule delivery.
  • Stimuli-responsive hydrogels show promise for closed-loop drug delivery systems.

Conclusions:

  • Careful consideration of polymer properties is essential for optimal drug delivery design.
  • Novel polymer combinations and stimuli-responsive materials will drive future innovations in drug delivery.
  • The field is rapidly evolving, with significant potential for improved therapeutic outcomes.

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