Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Berkeley Contact Lens Extended Wear Study. Part II : Clinical results.

K A Polse1, A D Graham, R E Fusaro

  • 1Morton D. Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley, California 94720-2020, USA.

Ophthalmology
|July 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term Renal Allograft Dysfunction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Ab initio chemical kinetic study on the reactions of ClO with C2H2 and C2H4.

The journal of physical chemistry. A·2010
Same author

Ab initio chemical kinetic study on Cl + ClO and related reverse processes.

The journal of physical chemistry. A·2010
Same author

A characterization of local LOINC mapping for laboratory tests in three large institutions.

Methods of information in medicine·2010
Same author

Enhanced catalytic activity of Ce(1-x)M(x)O2 (M = Ti, Zr, and Hf) solid solution with controlled morphologies.

Chemical communications (Cambridge, England)·2010
Same author

Shock tube study on the thermal decomposition of CH3OH.

The journal of physical chemistry. A·2010
Same journal

Diverse Conjunctival Adverse Events Associated with Tisotumab Vedotin.

Ophthalmology·2026
Same journal

The Answer Is Blowing in the Wind: Uncovering Hidden Glaucoma Risk Factors.

Ophthalmology·2026
Same journal

Nonsteroidal Anti-inflammatory Drug Use Reduces the Risk of Age-Related Macular Degeneration in Electronic Health Record Analysis: Signal or Solution?

Ophthalmology·2026
Same journal

Metastasis of Nasopharyngeal Squamous Cell Carcinoma to the Angle.

Ophthalmology·2026
Same journal

Endocrine Mucin-Producing Sweat Gland Carcinoma of Eyelid.

Ophthalmology·2026
Same journal

Multimodal Imaging of Optic Nerve Invasion in Unilateral Retinoblastoma.

Ophthalmology·2026
See all related articles

High oxygen transmissibility rigid gas-permeable (RGP) extended wear (EW) contact lenses significantly improve successful wear duration and reduce adverse events compared to medium-Dk lenses. This highlights oxygen

Area of Science:

  • Ophthalmology and Optometry
  • Corneal Physiology
  • Contact Lens Technology

Background:

  • Extended wear (EW) of rigid gas-permeable (RGP) contact lenses offers a refractive correction option for many individuals.
  • Understanding the impact of oxygen transmissibility (Dk/t) on ocular complications and wear success is crucial for patient safety.
  • Previous studies suggest a link between oxygen availability and contact lens-induced issues.

Purpose of the Study:

  • To evaluate clinical outcomes of 12-month rigid gas-permeable (RGP) extended wear (EW) contact lenses.
  • To determine if high oxygen transmissibility (Dk/t) RGP lenses reduce ocular complications during EW.
  • To assess if high-Dk/t lenses decrease the failure rate for maintaining 6-night per week RGP EW over 12 months.

Main Methods:

Related Experiment Videos

  • A randomized, concurrently controlled clinical trial involving 201 subjects adapted to RGP EW.
  • Subjects were randomized to wear either high Dk or medium-Dk RGP lenses for 12 months of 6-night EW.
  • Primary outcome measures included contact lens-associated keratopathies (CLAK), refractive error changes, corneal curvature, and EW survival.

Main Results:

  • Sixty-two percent of subjects in both medium-Dk and high-Dk groups completed 12 months of EW.
  • The medium-Dk group experienced a significantly greater probability of failure compared to the high-Dk group.
  • While overall complication risk was similar, CLAK events leading to termination were significantly higher (16 vs. 5) in the medium-Dk group, indicating adverse events were less reversible with lower oxygen.

Conclusions:

  • Corneal oxygen availability significantly impacts the success of RGP EW but not the initial onset of CLAK.
  • Higher rates of termination events in the medium-Dk group suggest corneal hypoxia is a key factor in CLAK development.
  • High-Dk RGP lenses appear safe and effective for refractive correction in individuals adapted to EW, though caution and monitoring are advised.