[Detection of viral aetiology in cerebral spinal fluid samples from 580 clinical cases]

To investigate the viral aetiology in cerebral spinal fluid (Csf) from 580 cases of CNS infection or FUO in Yuedong district from 1990 to 1997.

Virus isolation was done with Hep-2 and BHK-21 cells.

21 virus types of 5 kinds of viruses were isolated from 113 samples (19.5%). Clinically diagnosed diseases included viral encephalitis 17.8% (43/242), intracranial infection 20.2% (47/233), paralytic diseases 24.3% (9/37), FUO 37.5% (9/24), convulsion 16.0% (4/25), Guillain-Barre syndrome 5.3% (1/19). Virus infection included 11 cases of Poliovirus (constitutional ratio 0.0973, including 1 Polio-I, 8 Polio-II, 2 Polio-III); 54 cases of Coxsackie virus (0.477 9, including 11 CoxA24, 10 CoxBl, 2 Cox134, 3 CoxB5); 15 cases of ECHO virus (0.1327, including 4 ECHO-24, 3 ECRO-7, 2 ECHO-12 and each one of ECHO-3, 11,14,15,27,32); 25 cases of Enterovirus (0.2213, including 14 EV-70, 11 EV-71); 8 cases of Adenovirus (0.070 8, including 3 Adv-2, 3 Adv-3 and 2 Adv7). Results of different age groups indicated there was significant difference (P < 0.05) in virus detection rate in two age groups. Virus positive rates in different years were 1990-1991 14.2% (15/106), 1992-1993 14.1%(23/163), 1994-1995 26.1% (36/138), 1996-1997 22.5% (39/173), that showed a significant difference (P <0.05).

Virus infection rate of CNS diseases and FUO showed an a ascending trend, and the different virus types and kinds were isolated in different periods.