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[Changes in renal function in renal transplantation. Predictive factors for functional deterioration].
L A Jiménez del Cerro1, A Franco, F Rivera
1Servicio de Nefrología, Hospital General Universitario de Alicante Pintor Baeza, s/n. 03010 Alicante.
Summary
Donor age and proteinuria significantly impact renal transplant function. Younger donors and absence of proteinuria correlate with better long-term graft survival, highlighting key factors for intervention.
Area of Science:
- Nephrology
- Transplantation Immunology
- Clinical Medicine
Background:
- Renal transplants face challenges from reduced renal mass, rejection, and risk factors.
- Progression of renal insufficiency is a significant concern post-transplantation.
Purpose of the Study:
- To prospectively study renal function evolution in 285 cadaveric renal transplant recipients.
- To evaluate factors influencing the progression of renal insufficiency after transplantation.
Main Methods:
- Prospective study of 285 cadaveric renal transplant recipients on maintenance immunosuppression.
- Multivariate regression analysis of various factors affecting renal function.
- Monitoring of serum creatinine levels and proteinuria.
Main Results:
- A statistically significant increase in mean serum creatinine was observed (1.70 to 2.17 mg/dl).
- 57.8% of patients showed an increase in serum creatinine; 42.2% remained stable.
- Younger donor age and absence of initial proteinuria were associated with stable renal function.
Conclusions:
- Donor age and initial proteinuria are significant predictors of decreased renal function post-transplant.
- Identifying and managing these factors can potentially improve graft survival.
- Strategies to mitigate calcineurin inhibitor effects and reduce proteinuria are crucial.