Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probabilistic divergence measures for detecting interspecies recombination.

D Husmeier1, F Wright

  • 1Biomathematics & Statistics Scotland, SCRI, Invergowrie, Dundee, DD2 5DA, UK. dirk@bioss.ac.uk

Bioinformatics (Oxford, England)
|July 27, 2001
PubMed
Summary

This study introduces a graphical method to detect interspecies recombination in DNA sequence alignments. The approach uses probabilistic divergence measures to pinpoint recombinant regions, offering a novel tool for evolutionary biology research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Gastrocutaneous fistula: Laparoscopic resolution.

Revista de gastroenterologia de Mexico (English)·2022
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Area of Science:

  • Evolutionary Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Detecting interspecies recombination is crucial for understanding genome evolution.
  • Existing methods for identifying recombination events can be computationally intensive or lack precision.

Purpose of the Study:

  • To propose a novel graphical method for detecting interspecies recombination in DNA sequence alignments.
  • To provide a visually intuitive and computationally efficient approach for identifying recombinant regions.

Main Methods:

  • A fixed-size sliding window is applied to DNA sequence alignments.
  • Markov chain Monte Carlo simulations are used to calculate marginal posterior probabilities of tree topologies.
  • Two probabilistic divergence measures are computed and plotted along the alignment.

Related Experiment Videos

Main Results:

  • The graphical method successfully identifies recombinant regions in both synthetic and real-world DNA sequence alignments.
  • The proposed method demonstrates comparable or improved performance against established detection techniques.

Conclusions:

  • The developed graphical method offers an effective and visually interpretable approach for detecting interspecies recombination.
  • This method enhances the toolkit for analyzing complex evolutionary histories in DNA sequences.