Bone mineral content and bone mineral density in adolescent girls with anorexia nervosa--a longitudinal study
G Jagielska1, T Wolańczyk, J Komender
1Department of Child Psychiatry and Department of Internal Medicine and Nephrology, Medical University of Warsaw, Poland.
Objective:
Total body and lumbar spine bone mineral density (BMD-TB, BMD-L) and total body bone mineral content (BMC-TB) were measured to establish the course of bone demineralization in anorexia nervosa and the clinical factors influencing BMC-TB and BMD changes during treatment.
Method:
Forty-two girls with DSM III-R anorexia nervosa, age 14.7+/-2.4 years. BMC-TB, BMD-TB and BMD-L were measured in approximately 7-month intervals for 27.8+/-4.1 months using DXA.
Results:
Despite nutritional improvement, there was an initial decrease of BMD-L, and no change in BMC-TB and BMD-TB. an increase in BMC-TB and BMD was observed after approx. 21 months from the beginning of the study.
Conclusion:
The improvement in BMC-TB and BMD was related to changes in nutritional status and was significantly marked in younger patients, with earlier anorexia onset and before menarche.
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