Stability of amphotericin B in polyvinvl chloride intravenous infusion bags

The stability of solutions of amphotericin B as prepared for intravenous use in glass and polyvinyl chloride plastic (PVC) containers was studied. Four conditions were tested: contained within glass and exposed to light; contained in glass and shielded from light; contained in PVC and exposed to light; contained in PVC and shielded from light. Bioassays were performed on specimens collected from the containers periodically during 24 hours. Results of the bioassays revealed no significant loss of activity under any of the test conditions.