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DC-SIGN and LFA-1: a battle for ligand
D A Bleijs1, T B Geijtenbeek, C G Figdor
1Dept of Tumor Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Abstract:
The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.