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[Practical data on digestive tract oncogenetics]
1Consultation d'Oncogénétique Digestive, Service d'Hépato-Gastroentérologie, CHU Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris. sophie.grandjouan@cch.ap-hop-paris.fr
Annales De Medecine Interne
|July 28, 2001
Summary
Genetic testing for inherited cancer predispositions allows early cancer prevention in high-risk families. This approach aids clinicians in identifying at-risk individuals for predictive diagnosis and management.
Area of Science:
- Oncology
- Genetics
- Preventive Medicine
Context:
- Inherited cancer predispositions are well-established.
- Medical recommendations for high-risk families are evolving.
- Advances in molecular genetics enable predictive diagnosis.
Purpose:
- To outline the clinical and molecular genetic approaches for identifying individuals at high risk for inherited cancers.
- To illustrate practical issues in implementing predictive genetic testing for familial cancer syndromes.
- To facilitate physician access to emerging cancer prevention strategies.
Summary:
- The identification of genes associated with monogenic dominant cancer predispositions allows for predictive diagnosis in asymptomatic family members.
- Familial colorectal cancer predispositions are used as a model to demonstrate the practicalities of molecular testing.
- A summary table details referral requirements and procedures for molecular testing.
Impact:
- Enables early detection and intervention for hereditary cancer syndromes.
- Empowers clinicians to offer advanced cancer prevention options to at-risk families.
- Facilitates the integration of genetic testing into routine cancer prevention strategies.