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[Hyperprolactinemia in subclinical hypothyroidism].

D J Pietrobelli1, R Artese, J E Duhart

  • 1Quinta Cátedra de Medicina Interna, Hospital de Clínicas José de San Martín, Facultad de Medicina Universidad de Buenos Aires.

Medicina
|July 28, 2001
PubMed
Summary
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Subclinical hypothyroidism can cause hormonal imbalances, particularly affecting the gonadal axis in women. Further investigation is needed due to limited existing literature on this association.

Area of Science:

  • Endocrinology
  • Reproductive Medicine

Context:

  • Subclinical hypothyroidism (SCH) often presents asymptomatically.
  • When associated with lactotroph alterations, SCH can manifest clinically and biochemically.
  • Involvement of the gonadotrophic function is a key concern in such cases.

Purpose:

  • To investigate the clinical and biochemical manifestations of subclinical hypothyroidism associated with lactotroph alterations.
  • To assess the impact on the gonadal axis in affected women.
  • To highlight the scarcity of literature and propose systematic investigation.

Summary:

  • This report details findings in 11 women with hypothyroidism (5 stage I, 6 stage II).
  • Thyroid function was altered in all participants.
  • The gonadal axis was the most significantly affected system, indicating a strong link between hypothyroidism and reproductive hormonal dysfunction.

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Impact:

  • Highlights the potential for significant reproductive health issues in women with subclinical hypothyroidism.
  • Emphasizes the need for comprehensive evaluation beyond thyroid function tests.
  • Suggests a direction for future research into the complex interplay of endocrine axes.