Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Biological therapies for ulcerative colitis.

¹Gastrointestinal Unit and Center for the Study of IBD, Massachusetts General Hospital, Boston, USA.

Acta Gastro-Enterologica Belgica

|July 28, 2001

Summary

Biological therapies show promise for ulcerative colitis, an inflammatory bowel disease. Research is exploring probiotics, cytokine-directed treatments, and adhesion/recruitment therapies for better patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Erectile Dysfunction Is Highly Prevalent in Men With Newly Diagnosed Inflammatory Bowel Disease.

Inflammatory bowel diseases·2019

Same author

Long-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy.

Alimentary pharmacology & therapeutics·2018

Same author

Opportunistic screening for bone disease using abdominal CT scans obtained for other reasons in newly diagnosed IBD patients.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018

Same author

Letter: mucosal healing is associated with improved long-term outcomes in Crohn's disease - authors' reply.

Alimentary pharmacology & therapeutics·2016

Same author

Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn's disease.

Alimentary pharmacology & therapeutics·2015

Same author

Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target.

The American journal of gastroenterology·2015

Area of Science:

Gastroenterology and immunology research.
Focus on inflammatory bowel disease (IBD) therapeutics.

Background:

Inflammatory bowel disease (IBD) treatment often involves biological therapies.
Crohn's disease has more research than ulcerative colitis (UC).
UC presents a significant clinical need, especially for corticosteroid/5-aminosalicylate-resistant cases.

Purpose of the Study:

To review the current knowledge on biological therapies for ulcerative colitis (UC).
Highlight the distinct aspects of UC that facilitate therapeutic research.
Explore novel therapeutic avenues beyond those used for Crohn's disease.

Main Methods:

Review of existing literature on biological therapies for UC.
Analysis of distinct pathogenetic factors in UC.
Discussion of specific therapeutic strategies including probiotics, cytokine-directed therapies, adhesion/recruitment targeting, and restitution/repair.

Main Results:

Biological therapies are under investigation for UC.
UC's unique characteristics, like accessible mucosa and potential for local drug delivery, offer research advantages.
Distinct UC pathogenetic factors suggest unique therapeutic targets.

Conclusions:

Biological therapies represent a promising frontier for ulcerative colitis treatment.
Further research into UC-specific mechanisms can lead to novel and effective therapies.
Targeting inflammation, adhesion, recruitment, and promoting mucosal repair are key areas for UC biological therapy development.

Related Experiment Videos