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Bacteroides fragilis septicaemia and meningitis in early infancy

R W Cooke

    Archives of Disease in Childhood
    |March 1, 1975
    PubMed

    Insights

    A rare case of infant Bacteroides fragilis sepsis and meningitis, originating from a strangulated inguinal hernia, highlights treatment challenges. Chloramphenicol ultimately resolved the severe bacterial infection, leading to full recovery.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Neonatal Care

    Background:

    • Bacteroides fragilis infections are uncommon in infants and children.
    • Septicemia and meningitis pose significant risks in neonates.
    • Intra-abdominal sources, like hernias, can lead to severe sepsis.

    Purpose of the Study:

    • To report a unique case of recurrent Bacteroides fragilis sepsis and meningitis in an infant.
    • To discuss the source of infection and treatment strategies.
    • To review Bacteroides infections in pediatric populations.

    Main Methods:

    • Case report of a 6-week-old infant.
    • Identification of Bacteroides fragilis as the causative agent.
    • In vitro antibiotic sensitivity testing and clinical treatment course documentation.

    Main Results:

    • The infant developed recurrent Bacteroides fragilis sepsis and meningitis secondary to a perforated strangulated inguinal hernia.
    • Erythromycin showed in vitro sensitivity but provided only temporary clinical improvement.
    • Chloramphenicol was effective in eradicating the infection, leading to complete recovery.

    Conclusions:

    • Bacteroides fragilis can cause severe invasive infections in neonates, including meningitis.
    • Treatment requires careful consideration of antibiotic efficacy and source control.
    • Prompt diagnosis and appropriate antimicrobial therapy are crucial for favorable outcomes in neonatal sepsis.

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