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Vasopressin V2 receptor antagonists.

L L Wong¹, J G Verbalis

¹Department of Medicine, Division of Endocrinology and Metabolism, 232 Building D, Georgetown University School of Medicine, 4000 Reservoir Road NW, Washington, DC 20007, USA.

Cardiovascular Research

|July 31, 2001

Summary

New nonpeptide AVP V2 receptor antagonists offer a promising treatment for hyponatremia caused by syndrome of inappropriate antidiuretic hormone secretion (SIADH) and other water retention disorders.

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Area of Science:

Nephrology
Endocrinology
Pharmacology

Background:

Hyponatremia is common in patients with syndrome of inappropriate antidiuretic hormone secretion (SIADH), heart failure, and cirrhosis.
Current treatments for disorders of excess arginine vasopressin (AVP) are often suboptimal.

Purpose of the Study:

To review SIADH and water retention disorders.
To summarize preclinical and clinical studies on nonpeptide AVP V2 receptor antagonists.
To describe therapeutic indications, complications, and vascular effects of these agents.

Main Methods:

Literature review of preclinical and clinical studies.
Discussion of SIADH and water retention disorders.
Analysis of AVP V2 receptor antagonist development.

Main Results:

Nonpeptide AVP V2 receptor antagonists increase renal collecting tubule water permeability.
These antagonists promote water excretion and normalize hypoosmolar hyponatremia.
Published studies show promising preclinical and clinical data for these compounds.

Conclusions:

Nonpeptide AVP V2 receptor antagonists represent a promising therapeutic option for hyponatremia.
Further research is needed to fully understand their indications, complications, and vascular effects.

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