Related Experiment Videos
A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in
L Costabile1, S Gerli, C Manna
1"GENESIS" Center for Reproductive Medicine and Infertility Therapy, Rome, Italy. cdigerl@box2.tin.it
Objective:
To compare the effectiveness of i.m. P and 17alpha-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles.
Design:
Prospective, randomized study.
Setting:
Patients undergoing IVF-ET in our Centers.
Patient(S):
The inclusion criteria were the use of GnRH down-regulation and aged <40 years.
Intervention(S):
A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily).
Main Outcome Measure(S):
The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy.
Result(S):
No difference was found in the main outcome parameters considered.
Conclusion(S):
Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.