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Published on: February 10, 2014
Regulation of Na+ channel distribution in the nervous system
S D Novakovic1, R M Eglen, J C Hunter
1Roche Bioscience, Palo Alto, CA 94304-1397, USA. sanja.novakovic@roche.com
Abstract:
An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.
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