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[Comparing the bronchodilating effects of ipratropium bromide and theophylline]
Objective:
To compare the bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease(COPD).
Method:
In 26 patients, mean peak forced expiratory volume in 1 second(FEV1) were measured at the time before and 30 minute, 1, 2, 3, 4, 5, 6 hours after the drugs were administered in a double-blind, placebo-controlled crossover method.
Result:
The mean peak of FEV1, increased over baseline were 34% and 19% respectively, for ipratropium bromide and theophylline (P < 0.01), and the reaching duration were 1-2 hours and 2-3 hours, the proportion of patients attaining at least a 15% (P < 0.01) increase in the FEV1, responders were 19% and 50% (P < 0.01) respectively, for ipratropium bromide and theophylline. The average FEV1, increased during the 6-hours observation period were 18% for ipratropium bromide and 8% for theophylline (P < 0.01). The mean duration of FEV1 > 15% was 3.6 and 1.6 hours respectively.
Conclusion:
Ipratropium bromide nebulized is a more potent bronchodilator than the oral theophylline in patients with chronic airflow obstruction.