Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Procoagulant activity of platelets.

C G Kardinal, L T Wegener, L K Anderson

    Archives of Pathology
    |August 1, 1975
    PubMed
    Summary

    A new method accurately measures platelet procoagulant activity, correlating well with platelet counts below 100,000/cu mm. This aids in evaluating bleeding risks and platelet factor 3 release defects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Whole-exome sequencing for mutation detection in pediatric disorders of insulin secretion: Maturity onset diabetes of the young and congenital hyperinsulinism.

    Pediatric diabetes·2018
    Same author

    Epigenetic and gene expression analysis of ankylosing spondylitis-associated loci implicate immune cells and the gut in the disease pathogenesis.

    Genes and immunity·2017
    Same author

    Echocardiographic evaluation of dogs receiving 1:1 thiopental/propofol in a clinical setting.

    Veterinary anaesthesia and analgesia·2017
    Same author

    Characterization of phycobiliprotein and linker polypeptide genes in Fremyella diplosiphon and their regulated expression during complementary chromatic adaptation.

    Photosynthesis research·2014
    Same author

    Guest editor.

    Ochsner journal·2011
    Same author

    Can breast cancer be prevented?

    Ochsner journal·2011

    Area of Science:

    • Hematology
    • Clinical Chemistry

    Background:

    • Platelet procoagulant activity is crucial for hemostasis.
    • Accurate measurement of platelet function is clinically significant for assessing bleeding disorders.

    Purpose of the Study:

    • To evaluate a simplified, semiautomated, quantitative method for assessing platelet procoagulant activity.
    • To correlate clotting time with varying platelet concentrations.

    Main Methods:

    • A semiautomated quantitative assay was used to measure platelet procoagulant activity.
    • Plasma samples with diverse platelet concentrations were analyzed.

    Main Results:

    • Excellent correlation between platelet count and clotting time was observed for concentrations below 100,000 platelets/cu mm.
    • The strongest correlation was noted between 30,000 and 100,000 platelets/cu mm.
    • No significant alteration in clotting time was observed with platelet counts above 100,000/cu mm.

    Conclusions:

    • The method shows potential for evaluating patients with suspected platelet factor 3 release defects.
    • Findings align with clinical observations regarding bleeding risk at different platelet counts.

    Related Experiment Videos