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Updated: Aug 10, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
[Preliminary observation of immunotherapy on asthmatic guinea pig]
Objective:
To observe the effect of the anti-IL-5 monoclonal antibody(McAb) on eosinophils of the guinea pigs with asthma.
Method:
Sensitized guinea pigs by OVA were divided into two groups randomly, which were treated with the McAb and normal saline (NS), respectively. Difference of peripheral blood eosinophil count (PBEC) among basal pre-treatment and post-treatment, and the difference of bronchoalveolar lavage fluid eosinophil count (BALFEC) between two groups above were compared.
Result:
The PBEC after treatment with the McAb [(1.63 +/- 0.26) x 10(9)/L] was lower than that before treatment [(1.76 +/- 0.27) x 10(9)/L] (P < 0.05) and the BALFEC of treatment group with the McAb was lower than that with NS [(0.41 +/- 0.06) x 10(9)/L vs. (0.46 +/- 0.07) x 10(9)/L] (P < 0.05).
Conclusion:
The anti-IL-5 McAb has the ability to reduce the PBEC and the BALFEC.
