Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lupus profundus: not a benign disease.

E Grossberg1, L Scherschun, D P Fivenson

  • 1Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202-2608, USA.

Lupus
|August 2, 2001
PubMed
Summary

Severe lupus profundus, a skin condition, can lead to significant systemic illness and disfigurement. Early, aggressive treatment is crucial to prevent permanent damage and psychological distress.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemokine and inflammatory cytokine changes during chronic wound healing.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2006
Same author

Photoprotection by sunscreens.

American journal of clinical dermatology·2001
Same author

Leg ulcer diagnosis and management.

Dermatologic clinics·2001
Same author

Eosinophilic dermatosis of myeloproliferative disease: characterization of a unique eruption in patients with hematologic disorders.

Archives of dermatology·2001
Same author

Ulcerating plantar keratoderma in association with systemic lupus erythematosus.

Lupus·2001
Same author

Efficacy and tolerability of once-daily tazarotene 0.1% gel versus once-daily tretinoin 0.025% gel in the treatment of facial acne vulgaris: a randomized trial.

Cutis·2001

Area of Science:

  • Dermatology
  • Rheumatology
  • Systemic Autoimmune Diseases

Background:

  • Lupus profundus, a rare cutaneous lupus erythematosus variant, is often considered benign.
  • This study investigates severe cases and their systemic associations.

Observation:

  • Four patients with severe lupus profundus and systemic lupus erythematosus were reviewed.
  • All patients met criteria for systemic lupus erythematosus and exhibited significant disfigurement, including facial deformities, scalp ulcers, and scarring alopecia.

Findings:

  • Severe lupus profundus is linked to serious systemic complications.
  • Patients experienced disfigurement, psychological distress (clinical depression), and resistance to conservative treatments, necessitating aggressive, long-term therapy.

Implications:

  • Extensive lupus profundus may indicate more severe underlying systemic disease.
  • Early, aggressive treatment is recommended to prevent permanent disfigurement and associated psychological consequences.

Related Experiment Videos