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Kashin-Beck disease: a historical overview
1The University of the Air, Kyoto Education Center, Japan.
International Orthopaedics
|August 3, 2001
Summary
Kashin-Beck disease (KBD) is linked to endemic water contaminants causing salivary gland and bone degeneration. Early research suggested parotin deficiency, while later studies identified specific acids in water as a cause, recommending water purification for prevention.
Area of Science:
- Endocrinology
- Environmental Health
- Rheumatology
Background:
- Kashin-Beck disease (KBD) is an endemic osteochondropathy first reported in Korea in 1919.
- Extensive research in China and Japan during the 20th century investigated its etiology and clinical manifestations.
Purpose of the Study:
- To review the historical research and proposed theories regarding the cause of Kashin-Beck disease.
- To summarize findings on the environmental factors and potential treatments for KBD.
Main Methods:
- Historical review of epidemiological, clinical, and experimental studies on KBD.
- Analysis of early research on salivary gland degeneration and bone/joint changes in affected populations and animal models.
Main Results:
- Early theories proposed parotin deficiency, with some success in early-stage KBD treatment.
- Later research identified ferulic acid and p-hydroxy-cinnamic acid in endemic water as causative agents for salivary gland degeneration in rats.
- KBD was found to be absent in Japan, except in individuals with prior residence in endemic areas of China.
Conclusions:
- Environmental contaminants in drinking water are implicated in KBD pathogenesis.
- Water purification methods like boiling or activated charcoal are recommended for KBD prevention.
- Understanding the historical research provides insights into the environmental etiology of KBD.