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Updated: Aug 1, 2026

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

[Bacterial translocation from the gastrointestinal tract: catalyst of multiple organ dysfunction syndrome]

S Khinev, D Tsoneva, K Dafinova

    Khirurgiia
    |August 4, 2001
    PubMed

    Insights

    Bacterial translocation (BT) contributes to multiple organ dysfunction syndrome (MODS) after surgery. Amikacin plus Clindamycin showed a good therapeutic effect for patients with MODS and sepsis.

    Area of Science:

    • Gastroenterology
    • Critical Care Medicine
    • Infectious Diseases

    Background:

    • Intestinal insufficiency, marked by abnormal gut microbiota, barrier dysfunction, and bacterial translocation (BT), is implicated in the pathogenesis of multiple organ dysfunction syndrome (MODS).
    • MODS significantly worsens patient outcomes, particularly in intensive care unit (ICU) patients following major abdominal surgery.

    Purpose of the Study:

    • To review scientific and clinical evidence on the role of BT in MODS pathogenesis.
    • To evaluate the efficacy of Amikacin plus Clindamycin as a novel therapeutic strategy for improving outcomes in MODS and sepsis patients.

    Main Methods:

    • Analysis of patients with diffuse peritonitis of various origins.
    • Patients were grouped based on antibiotic treatment: standard antibiotics versus Amikacin plus Clindamycin.
    • Microbiological analyses were performed on abdominal cavity samples from patients with laparostomy.

    Main Results:

    • The Amikacin plus Clindamycin combination was well-tolerated by patients.
    • This antibiotic regimen demonstrated a good therapeutic effect in the subgroup of patients studied.

    Conclusions:

    • Bacterial translocation plays a crucial role in the development of MODS.
    • Amikacin plus Clindamycin presents a promising therapeutic option for managing MODS and sepsis, improving patient outcomes.

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