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Bioartificial polymeric materials based on polysaccharides.

M G Cascone1, N Barbani, C Cristallini

  • 1Department of Chemical Engineering, University of Pisa, Italy. mg.cascone@ing.unipi.it

Journal of Biomaterials Science. Polymer Edition
|August 4, 2001
PubMed
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New bioartificial polymeric materials blend natural polysaccharides with synthetic polymers like poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA). These materials show promise as advanced dialysis membranes and drug delivery systems.

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Bioartificial polymeric materials offer tunable properties for biomedical applications.
  • Blending natural polysaccharides with synthetic polymers like poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) can create novel materials.
  • Understanding polymer blend miscibility is crucial for material performance.

Purpose of the Study:

  • To prepare and characterize bioartificial polymeric materials from polysaccharide/synthetic polymer blends.
  • To evaluate the physico-chemical, mechanical, and biological properties of these blends.
  • To establish potential applications for these materials, such as in dialysis and drug delivery.

Main Methods:

  • Preparation of films and hydrogels from polysaccharide/synthetic polymer blends.

Related Experiment Videos

  • Characterization using differential scanning calorimetry, dynamic mechanical thermal analysis, and scanning electron microscopy.
  • In vitro release tests to assess drug delivery capabilities and transport properties.

    • Main Results:

    • Dextran/poly(acrylic acid) (PAA) blends showed perfect miscibility.
    • Dextran/PVA, chitosan/PVA, starch/PVA, and gellan/PVA blends behaved as two-phase systems with potential interactions.
    • Cross-linked starch/PVA films exhibited comparable or superior transport properties to commercial dialysis membranes.
    • Dextran/PVA and chitosan/PVA hydrogels demonstrated controlled release of human growth hormone.

    Conclusions:

    • Polysaccharide/synthetic polymer blends can be tailored for specific biomedical applications.
    • Starch/PVA films are suitable for use as dialysis membranes.
    • Dextran/PVA and chitosan/PVA hydrogels show potential as effective drug delivery systems with tunable release rates.