Related Experiment Video

Updated: Aug 8, 2026

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
09:50

Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement

Published on: October 1, 2014

Prevention and treatment of veno-occlusive disease

A A Pegram1, L D Kennedy

  • 1Wake Forest University Baptist Medical Center, Winston-Salem NC 27157, USA. apegram@wfubmc.edu

The Annals of Pharmacotherapy
|August 4, 2001
PubMed

Insights

Current options for preventing and treating veno-occlusive disease in bone marrow transplant patients are limited. Ursodiol shows promise for prevention, while defibrotide or glutamine plus vitamin E may aid treatment.

Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Background:

  • Veno-occlusive disease (VOD) is a serious complication following bone marrow transplantation.
  • Effective preventive and therapeutic strategies for VOD remain a significant clinical challenge.

Purpose of the Study:

  • To review existing literature on the prevention and treatment of veno-occlusive disease in bone marrow transplant recipients.
  • To identify promising agents based on current evidence.

Main Methods:

  • Comprehensive literature search of MEDLINE (1966-1999) using keywords 'veno-occlusive disease' and 'bone marrow transplantation'.
  • Inclusion of relevant articles from reference lists.
  • Evaluation of clinical trials, case-control studies, and case reports.

Main Results:

  • Several agents, including heparin, ursodiol, and glutamine, have been investigated for VOD prevention, but no regimen is definitively established.
  • Tissue plasminogen activator has been studied for treatment, but its safety and efficacy are not clear.
  • Other potential treatments include defibrotide and glutamine with vitamin E.

Conclusions:

  • Ursodiol is a promising agent for VOD prevention.
  • Defibrotide or glutamine plus vitamin E show potential for VOD treatment.
  • Further high-quality clinical trials are essential to define optimal VOD management in bone marrow transplant patients.
Abstract

More Related Videos

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane08:05

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Rodent Inferior Vena Cava Venoplasty Balloon Model05:44

Rodent Inferior Vena Cava Venoplasty Balloon Model

Published on: May 24, 2024

Related Concept Videos

Venous Return01:04

Venous Return

The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system as it...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...