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RNAi Screening to Identify Postembryonic Phenotypes in C. elegans
09:40

RNAi Screening to Identify Postembryonic Phenotypes in C. elegans

Published on: February 13, 2012

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

S W Knight1, B L Bass

  • 1Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 50 North Medical Drive, Room 211, Salt Lake City, UT 84132, USA.

Science (New York, N.Y.)
|August 4, 2001
PubMed

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...