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Published on: December 23, 2016
Condyloma acuminatum in a cynomolgus monkey (Macaca fascicularis)
H P Gordon1, D A Reim, S A McClain
1The Division of Laboratory Animal Resources and Department of Dermatology, State University of New York at Stony Brook, Stony Brook, NY 11794-8611, USA.
Abstract:
Condyloma acuminatum was found on the penile shaft and glans of a wild-caught cynomolgus monkey. The characteristic cauliflower-like, digitated lesions corresponded histopathologically with epidermal hyperplasia, hyperkeratosis, hypergranulosis, pallor of the mid-spinous zone, and crowding of keratinocytes. Electron microscopy revealed 10 intranuclear viral particles. In situ hybridization studies using human DNA probes (pan-Human Papillomavirus [HPV] 6/11, HPV 16/18, and HPV 31/33) all failed to hybridize. Polymerase chain reaction using papillomavirus probes MY09, MY11, GP5, and GP6 failed to amplify HPV DNA. We conclude that this lesion likely is a viral-induced condyloma but that the virus is not detectable by using presently available human or monkey papillomavirus probes.
