Related Experiment Video
Updated: Aug 1, 2026
06:25
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Condyloma acuminatum in a cynomolgus monkey (Macaca fascicularis)
H P Gordon1, D A Reim, S A McClain
1The Division of Laboratory Animal Resources and Department of Dermatology, State University of New York at Stony Brook, Stony Brook, NY 11794-8611, USA.
Contemporary Topics in Laboratory Animal Science
|August 7, 2001
Summary
A wild cynomolgus monkey presented with condyloma acuminatum lesions. Despite viral particles, human and monkey papillomavirus probes could not detect the causative agent, suggesting a novel or unidentifiable virus.
Area of Science:
- Veterinary Pathology
- Primate Virology
- Dermatology
Background:
- Condyloma acuminatum, a sexually transmitted infection, is typically caused by specific Human Papillomavirus (HPV) types.
- Lesions in non-human primates can offer insights into disease pathogenesis and viral evolution.
Purpose of the Study:
- To characterize histopathologically and virologically a condyloma acuminatum-like lesion in a cynomolgus monkey.
- To identify the potential viral etiology of the observed lesion using molecular techniques.
Main Methods:
- Histopathological examination of penile lesions.
- Electron microscopy to visualize viral particles.
- In situ hybridization and Polymerase Chain Reaction (PCR) using various HPV and papillomavirus probes.
Main Results:
- Macroscopic and microscopic features consistent with condyloma acuminatum were observed.
- Electron microscopy confirmed the presence of intranuclear viral particles.
- In situ hybridization and PCR failed to detect known human or monkey papillomaviruses.
Conclusions:
- The lesion is likely a viral-induced condyloma, but the causative agent could not be identified with current human or monkey papillomavirus detection methods.
- Further research is needed to characterize the novel virus responsible for this simian condyloma.
