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Updated: Jun 20, 2026

Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
Failed air supply to individually ventilated caging system causes acute hypoxia and mortality of rats
Michael J Huerkamp1, Wesley D Thompson, Noel D M Lehner
1Division of Animal Resources, Emory University, Atlanta, Georgia 30322, USA.
Abstract:
Greater than 30% mortality was observed unexpectedly in rat pups of weaning age kept with their dams in individually ventilated cages (IVC). A subsequent controlled study involving an induced electrical power failure that halted ventilation of IVC containing rat dams and pups showed that oxygen concentrations in the air in individual cages were rapidly depleted to less than 10% in 1 h. In a separate incident during which electrical power to IVC was inadvertently disconnected, rats died within 60 min of loss of power to IVC. The loss of electrical power to IVC housing rats is potentially a life-threatening condition requiring an immediate response and affirms the consideration of emergency (back-up) electrical power where these systems are used.
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