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[Experimental study in rabbit on repair of radial bone defect by bioactive degradable polymer]
1Department of Orthopedic Surgery, Norman Bethune University of Medical Sciences, Changchun Jilin, P.R. China 130021.
Objective:
To investigate the availability of bone defect repair by degradable porous polycaprolactam (PCL) as the carrier of bone morphogenetic protein (BMP).
Methods:
Three different kinds of bone substitutes, including decalcified bone matrix, PCL-BMP compounds and simple PCL, were implanted into the radial bone defects in 36 rabbits, and in the other 12 rabbits the bone defects were left untreated as control. X-ray examination, X-ray morphometry, histological and electron microscopic observation were performed at different time after operation.
Results:
The quantity of new bone formation in PCL-BMP group was prior to that in simple PCL group. The pattern and speed of bone defect repair in PCL-BMP group were similar to those in decalcified bone matrix. Electron microscopic observation showed that the PCL-BMP group degraded faster than simple PCL group, which was more suitable for bone repair.
Conclusion:
PCL is a good carrier of BMP with potential for clinical use.